{"id":29414,"date":"2019-08-19T23:42:38","date_gmt":"2019-08-19T23:42:38","guid":{"rendered":"https:\/\/antonini.med.br\/?p=29414"},"modified":"2022-02-15T02:38:30","modified_gmt":"2022-02-15T02:38:30","slug":"sintese-da-aldosterona","status":"publish","type":"post","link":"https:\/\/antonini.psc.br\/?p=29414","title":{"rendered":"S\u00edntese da aldosterona"},"content":{"rendered":"<div class=\"blogentry\" style=\"text-align: justify;\">Aldosterona \u00e9 um horm\u00f4nio produzido nos rins e controla o equil\u00edbrio eletrol\u00edtico do corpo.Sua s\u00edntese parte da pregnenolona, cujo precursor \u00e9 o colesterol, j\u00e1 visto anteriormente.<!--more--><\/p>\n<div style=\"text-align: center;\">[singlepic id=816 w= h= float=center]<\/div>\n<\/div>\n<div class=\"blogentry\">&nbsp;<\/div>\n<div class=\"blogentry\" style=\"text-align: justify;\">A primeira etapa da s\u00edntese ocorre pela a\u00e7\u00e3o da enzima 3-desidrogenase, que retira um hidrog\u00eanio e desloca a dupla liga\u00e7\u00e3o do segundo anel para o primeiro e forma uma cetona, convertendo a pregnenolona em pregesterona, conforme a rea\u00e7\u00e3o abaixo:<\/p>\n<div style=\"text-align: center;\">[singlepic id=819 w= h= float=center]<\/div>\n<\/div>\n<div class=\"blogentry\">&nbsp;<\/div>\n<div class=\"blogentry\" style=\"text-align: justify;\">Em seguida, a enzima 21-hidroxilase implanta uma hidroxila na posi\u00e7\u00e3o 21, formando a 11-deoxi-corticosterona, abaixo:<\/p>\n<div style=\"text-align: center;\">[singlepic id=823 w= h= float=center]<\/div>\n<\/div>\n<div class=\"blogentry\">&nbsp;<\/div>\n<div class=\"blogentry\" style=\"text-align: justify;\">A 11-deoxi-corticosterona sofre nova hidroxila\u00e7\u00e3o, atrav\u00e9s da a\u00e7\u00e3o da enzima 11-hidroxilase, recebendo uma hidroxila na posi\u00e7\u00e3o 11 e convertendo-se em corticosterona:<\/p>\n<div style=\"text-align: center;\">[singlepic id=824 w= h= float=center]<\/div>\n<\/div>\n<div class=\"blogentry\">&nbsp;<\/div>\n<div class=\"blogentry\" style=\"text-align: justify;\">J\u00e1 a corticosterona sofrer\u00e1, tambem, uma hidroxila\u00e7\u00e3o via enzima 18-hidroxilase, transformando-se em aldosterona:<\/div>\n<div class=\"blogentry\">[singlepic id=827 w= h= float=center]<\/p>\n<p style=\"text-align: center;\">[<a href=\"javascript:history.go(-1)\">Voltar<\/a>]<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Aldosterona \u00e9 um horm\u00f4nio produzido nos rins e controla o equil\u00edbrio eletrol\u00edtico do corpo.Sua s\u00edntese parte da pregnenolona, cujo precursor \u00e9 o colesterol, j\u00e1 visto anteriormente.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[80],"tags":[],"class_list":["post-29414","post","type-post","status-publish","format-standard","hentry","category-bioquimica"],"_links":{"self":[{"href":"https:\/\/antonini.psc.br\/index.php?rest_route=\/wp\/v2\/posts\/29414","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/antonini.psc.br\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/antonini.psc.br\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/antonini.psc.br\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/antonini.psc.br\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29414"}],"version-history":[{"count":6,"href":"https:\/\/antonini.psc.br\/index.php?rest_route=\/wp\/v2\/posts\/29414\/revisions"}],"predecessor-version":[{"id":29619,"href":"https:\/\/antonini.psc.br\/index.php?rest_route=\/wp\/v2\/posts\/29414\/revisions\/29619"}],"wp:attachment":[{"href":"https:\/\/antonini.psc.br\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29414"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/antonini.psc.br\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=29414"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/antonini.psc.br\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=29414"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}