{"id":75331,"date":"2025-12-07T15:37:12","date_gmt":"2025-12-07T15:37:12","guid":{"rendered":"https:\/\/antonini.com.br\/?p=75331"},"modified":"2025-12-07T15:37:12","modified_gmt":"2025-12-07T15:37:12","slug":"o-milagroso-ozimpic-nao-corrige-a-problema-raiz-da-obesidade","status":"publish","type":"post","link":"https:\/\/antonini.psc.br\/?p=75331","title":{"rendered":"O milagroso Ozimpic n\u00e3o corrige o problema base da obesidade"},"content":{"rendered":"<p style=\"text-align: justify;\">A semaglutida n\u00e3o resolve o problema b\u00e1sico da obesidade, que \u00e9 o desequil\u00edbrio entre os complexos enzim\u00e1ticos de \u00e1cido graxo-sintetase e da 3-HMG-CoA-sintetase.<!--more--><\/p>\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" class=\"wp-image-75661\" src=\"https:\/\/antonini.psc.br\/wp-content\/uploads\/2025\/12\/semaglutide-cas-99291-20-0e7ff77019046639829104340.jpeg\" alt=\"\"\/>\n<figcaption class=\"wp-element-caption\">semaglutida<\/figcaption>\n<\/figure>\n\n<p style=\"text-align: justify;\">\u00c9 apenas um agonista do receptor de GLP-1 (pept\u00eddeo semelhante ao glucagon tipo 1) que engana o receptor, fazendo com que ele estimule o p\u00e2ncreas a aumentar a produ\u00e7\u00e3o de insulina. Esta aumenta o n\u00famero de receptores de glicose nas membranas celulares, reduzindo a glicose livre no plasma.<\/p>\n<p style=\"text-align: justify;\">O grande problema desse mecanismo de a\u00e7\u00e3o farmacol\u00f3gico \u00e9 o fen\u00f4meno fisiol\u00f3gico conhecido como &#8220;up-regulation&#8221; (regula\u00e7\u00e3o para cima) de receptores, algo que poder\u00e1 cobrar um alto pre\u00e7o dos usu\u00e1rios no futuro, especialmente pelo aumento da probabilidade de induzir o desenvolvimento de diabetes.<\/p>\n<p style=\"text-align: center;\"><iframe loading=\"lazy\" src=\"\/\/www.youtube.com\/embed\/Bw5RweWVDlo\" width=\"560\" height=\"314\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p style=\"text-align: center;\">[<a href=\"javascript:history.go(-1)\">Voltar<\/a>]<\/p>","protected":false},"excerpt":{"rendered":"<p>A semaglutida n\u00e3o resolve o problema b\u00e1sico da obesidade, que \u00e9 o desequil\u00edbrio entre os complexos enzim\u00e1ticos de \u00e1cido graxo-sintetase e da 3-HMG-CoA-sintetase.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14,124],"tags":[],"class_list":["post-75331","post","type-post","status-publish","format-standard","hentry","category-farmacologia","category-saude"],"_links":{"self":[{"href":"https:\/\/antonini.psc.br\/index.php?rest_route=\/wp\/v2\/posts\/75331","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/antonini.psc.br\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/antonini.psc.br\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/antonini.psc.br\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/antonini.psc.br\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=75331"}],"version-history":[{"count":0,"href":"https:\/\/antonini.psc.br\/index.php?rest_route=\/wp\/v2\/posts\/75331\/revisions"}],"wp:attachment":[{"href":"https:\/\/antonini.psc.br\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=75331"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/antonini.psc.br\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=75331"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/antonini.psc.br\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=75331"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}